DEMENTIA
Also known as
Neuro-cognitive disorder.
Dementia is a term used
to describe for loss of memory, language, problem-solving & other thinking
abilities, that are severe enough to interfere with daily life.
It is not a specific
disease, but several diseases can cause dementia.
Many things can cause dementia. It happens when the parts of brain used for learning, memory, decision making, and language are damaged or diseased.
Causes –
Dementia is caused by
damage to or loss of nerve cells and their connection in the brain cells. This
damage to brain cells interferes with ability of brain cells to communicate to
each other. When brain cells cannot communicate normally, thinking, behavior
and feelings can be affected.
The brain has many
distinct regions, each of which is responsible for different functions (for
example, memory, judgement and movement). When cells in a particular region are
damaged, that region cannot carry out its functions normally.
Sign and Symptoms –
Early signs & symptoms are :
-
Forgetting
things or recent event
-
Losing or
misplace things
-
Getting lost
when walking or driving
-
Losing track
of time
-
Difficulties
solving problem
-
Difficulties
making decisions
-
Problem
following conservations
-
Difficulties
performing familiar tasks
-
Misjudging
distances to objects visually
Common changes in mood and behavior include :
-
Feeling
anxious, sad or anger about memory loss
-
Personality
changes
-
Inappropriate
behavior
-
Withdrawal
from work or social activities
-
Being less
interest in other people’s emotions
Dementia affects each
person in a different way, depending upon the underlying causes, other health
conditions & the person’s cognitive functioning before becoming ill.
Most symptoms become
worse over time, while others might disappear or only occur in the later stages
of dementia.
Common forms of dementia –
1. Progressive Dementias :
·
Alzheimer’s
disease – this is the
most common cause of dementia.
Although
not all type of dementia causes Alzheimer’s disease are known, experts do know
that a small percentage are related to mutations of three genes, which can be
passes down from parent to child. While several genes are probably involved in
Alzheimer’s disease, one important gene that increase risk is apolipoprotein E4
(APOE).
Alzheimer’s
disease patients have plaques and tangles in their brains. Plaques and clumps
of a protein called beta-amyloid and tangles are fibrous tangles made up of tau
protein. It’s through that these clumps damage healthy neurons and the fibers
connecting them.
·
Vascular
dementia –
This
type of dementia is caused by damage to the vessels that supply blood to the
brain. Blood vessel problems can cause strokes or affect the brain in other
ways, such as by damaging the fibers in the white matter of the brain.
The most
common sign of vascular dementia include difficulties with problem-solving,
slowed thinking and loss of focus and organization. These tend to be more
noticeable than memory loss.
·
Lewy
body dementia –
Lewy
bodies are abnormal balloon like clumps of protein that have been found in the
brain of people with Lewy body dementia, Alzheimer’s disease, and Parkinson’s
disease. This is one of the more common types of dementia.
·
Frontotemporal
dementia –
This is
a group of diseases characterized by the breakdown of nerve cells and their
connections in the frontal and temporal lobes of the brain. These are the areas
generally associated with personality, behavior, and language.
Common
symptoms affect behavior, personality, thinking, judgement, and language and
movement.
·
Mixed
dementia –
Autopsy
studies of the brains of people 80 and older who had dementia indicate that
many had a combination of several causes, such as Alzheimer’s disease, vascular
dementia, and Lewy body dementia. Studies are ongoing to determine how having
mixed dementia affect symptoms and treatments.
2. Other disorders linked to Dementia :
·
Huntington’s
disease –
Caused
by genetic mutation, this disease causes certain nerve cells in brain and
spinal cord to waste away. Sign & symptoms including a severe decline in
thinking (cognitive) skill, usually appear around age 30 & 40.
·
Traumatic
brain injury (TBI) –
This
condition is most often caused by repetitive head trauma. Boxers, football
players or soldiers might develop TBI.
Depending
on the part of the brain that’s injured, this condition can cause dementia
signs and symptoms such as depression, explosiveness, memory loss and impaired
speech. TBI may also cause Parkinsonism. Symptoms might not appear until years
after trauma.
·
Creutzfeldt-Jakob
disease –
This
rare brain disorder usually occurs in people without risk factors. This
condition might be due to deposits if infectious proteins called prions. Signs
and symptoms of this fatal condition usually appear after age 60.
This
disease usually has no known cause but can be inherited. It may also be caused
by exposure to diseased brain or nervous system tissue, such as from a cornea
transplant.
·
Parkinson’s
disease –
Many
people with Parkinson’s disease eventually develop dementia symptoms
(Parkinson’s disease dementia).
Risk Factors –
Many factors can eventually contribute to dementia. Some
factors, such as age, can’t be changed. Others can be addressed to reduce risk.
1. Risk factors can’t be changed are :
·
Age – The risk rises as you age, especially after
age 65. However, dementia isn’t normal part of aging, and dementia can occurs
in younger people.
·
Family
history – having family history of
dementia puts you at greater risk of developing the condition. However, many
people with family history never develop symptoms and many people without a
family history do.
·
Down
syndrome – by middle age, many
people with down syndrome develop early onset Alzheimer’s disease.
2. Risk factor can be changes are :
You might be able to control the
following risk factors for dementia.
·
Diet
& exercise – research
show that lack of exercise increases the risk of dementia. Research indicates a
greater incidence of dementia in people who eat unhealthy diet compared those
who follow healthy diet.
·
Excessive
alcohol use – drinking
large amount of alcohol has long been known to cause brain changes. Several
studies and reviews found that alcohol use disorders were linked to an
increased risk of dementia, particularly early-onset dementia.
·
Cardiovascular
risk factor – these
include high blood pressure (hypertension), high cholesterol, buildup of fats
in artery walls (atherosclerosis) & obesity.
·
Depression
– although not yet well-understood, late life
depression might indicate the development of dementia.
·
Diabetes
– having diabetes may increase risk of
dementia, especially if it’s poorly controlled.
·
Smoking
– smoking might increase risk of developing
dementia & blood vessel disease.
·
Air
pollution – studies have
found that air pollution exposure particularly from traffic exhaust and burning
wood is associated with greater dementia risk.
·
Head
trauma – people who have had a
severe head trauma have greater risk of dementia. Several studies found that in
people aged 50 years or older who had TBI, Alzheimer’s disease increase risk of
dementia.
Prevention :
There’s no sure way to prevent dementia but there are steps
that might help.
·
Keep mind
active – mentally stimulating activities, such as reading, solving puzzles
& playing word games & memory training might delay the onset of
dementia and decreases its effects.
·
Be physically
& socially active – physical activity and social interaction might delay
the onset of dementia and reduce its symptoms.
·
Quit smoking
– smoking in middle age and beyond might increase risk of dementia & blood
vessel conditions. Quitting smoking might reduce risk and improve health.
·
Manage
cardiovascular risk factors – treating high blood pressure, high cholesterol,
and diabetes, may reduce the risk of dementia.
·
Maintain
healthy diet – good and healthy diet reduce or lower risks of dementia.
· Treat haring problems – people with hearing loss have a greater chance of developing cognitive decline. Early treatment of hearing loss, such as use of hearing aids, might help decrease risk of dementia.

